![]() ![]() Since microfluidic devices have become a more prominent tool in biological studies, understanding the transport of oxygen and other biological molecules in microfluidic devices is critical for maintaining a physiologically relevant environment. The simulations demonstrate that microfluidic device geometry plays a critical role in molecule exchange, for instance, changing the orientation of the short wide microfluidic channel results in a 97.17% increase in oxygen exchange. 3D simulations of oxygen transport were performed to simulate oxygen distribution throughout the device. Our objective is twofold: (1) optimize the parameters of our system and (2) develop a method to assess the oxygen distribution in complex 3D microfluidic device geometries. The microfluidic device is fabricated using soft lithography in polydimethyl-siloxane, an oxygen permeable material. The system is composed of a microfluidic device stacked on top of a large, gas impermeable flow channel with a hole to allow gas exchange. In the present study, oxygen transport simulations were used to optimize the geometric design parameters for a similar system which is easier to fabricate. The objective was to determine if a steep oxygen gradient could be developed in the channel to cause a rapid decrease in hemoglobin oxygen saturation in order to measure the corresponding levels of ATP released from the red blood cells. Previous work has focused on the feasibility of developing a microfluidic system to measure the dynamics of ATP release. Since red blood cells serve as an oxygen sensor for the circulatory system, the dynamics of ATP release determine the effectiveness of red blood cells to relate the oxygen levels to the vessels. Red blood cells play a crucial role in the local regulation of oxygen supply in the microcirculation through the oxygen dependent release of ATP. Rouse, editor, Engineering Hydraulics: Proceedings of the Fourth Hydraulics Conference, chapter 6, pages 387–443. ![]() Design of pressure-driven microfluidic networks using electric circuit analogy. In 21st Australasian Fluid Mechanics Conference, 2018. Impulsively generated incompressible two-phase flow and the Asai thermal ink-jet model. Cambridge University Press, 6th edition, 1932. Superconvergence phenomenon in the finite element method arising from averaging gradients. Some remarks on the Volta force and seat of electro-motive forces questions, and on impressed force and potential in condenser circuits. Introduction, Partial differential equations and functional analysis. Gmsh: A 3-D finite element mesh generator with built-in pre- and post-processing facilities. Kron reduction of graphs with applications to electrical networks. Model for fluid ejection and refill in an impulse drive jet. Three-dimensional calculation of bubble growth and drop ejection in a bubble jet printer. Bubble dynamics in boiling under high heat flux pulse heating. For a system discretized with finite elements, a third method is proposed for computing reciprocal inertance coefficients which requires only the stiffness matrix and the solution vectors and no numerical differentiation. Green's identity converts these coefficients to domain integrals of kinetic energy. The reciprocal inertance coefficients are defined by the boundary fluxes of potential flows. For a vessel with one inlet and outlet, this is a single quantity for multiple ports the generalization is a singular reciprocal inertance matrix which acts on the port-impulses to give the corresponding inflows. The immediate impulse-response of a confined incompressible fluid is characterized by inertance. Impulsively generated flow, Kron reduction, multiport vessels, hydraulic inertanc Abstract ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |